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Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

Previous reports have shown that individual neurons of the brain can display somatic genomic mosaicism of unknown function. In this study, we report altered genomic mosaicism in single, sporadic Alzheimer's disease (AD) neurons characterized by increases in DNA content and amyloid precursor pro...

詳細記述

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書誌詳細
出版年:eLife
主要な著者: Bushman, Diane M, Kaeser, Gwendolyn E, Siddoway, Benjamin, Westra, Jurgen W, Rivera, Richard R, Rehen, Stevens K, Yung, Yun C, Chun, Jerold
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337608/
https://ncbi.nlm.nih.gov/pubmed/25650802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05116
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