Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

Previous reports have shown that individual neurons of the brain can display somatic genomic mosaicism of unknown function. In this study, we report altered genomic mosaicism in single, sporadic Alzheimer's disease (AD) neurons characterized by increases in DNA content and amyloid precursor pro...

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Foilsithe in:eLife
Main Authors: Bushman, Diane M, Kaeser, Gwendolyn E, Siddoway, Benjamin, Westra, Jurgen W, Rivera, Richard R, Rehen, Stevens K, Yung, Yun C, Chun, Jerold
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2015
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337608/
https://ncbi.nlm.nih.gov/pubmed/25650802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05116
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