Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

Previous reports have shown that individual neurons of the brain can display somatic genomic mosaicism of unknown function. In this study, we report altered genomic mosaicism in single, sporadic Alzheimer's disease (AD) neurons characterized by increases in DNA content and amyloid precursor pro...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:eLife
Main Authors: Bushman, Diane M, Kaeser, Gwendolyn E, Siddoway, Benjamin, Westra, Jurgen W, Rivera, Richard R, Rehen, Stevens K, Yung, Yun C, Chun, Jerold
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337608/
https://ncbi.nlm.nih.gov/pubmed/25650802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05116
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados