Differential neuroprotective and anti-inflammatory effects of L-type voltage dependent calcium channel and ryanodine receptor antagonists in the substantia nigra and locus coeruleus

Neuroinflammation and degeneration of catecholaminergic brainstem nuclei occur early in neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Neuroinflammation increases levels of pro-inflammatory cytokines and reactive oxygen species which can alter neuronal calcium (Ca(+2...

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Veröffentlicht in:J Neuroimmune Pharmacol
Hauptverfasser: Hopp, Sarah C., Royer, Sarah E., D’Angelo, Heather M., Kaercher, Roxanne M., Fisher, David A., Wenk, Gary L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336597/
https://ncbi.nlm.nih.gov/pubmed/25318607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-014-9568-7
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