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Neuroprotective effects of intranasal IGF-1 against neonatal lipopolysaccharide-induced neurobehavioral deficits and neuronal inflammation in the substantia nigra and locus coeruleus of juvenile rats

Neonatal lipopolysaccharide (LPS) exposure-induced brain inflammation resulted in motor dysfunction and brain dopaminergic neuronal injury, and increased the risks of neurodegenerative disorders in adult rats. Our previous studies showed that intranasal administration of insulin-like growth factor-1...

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Dades bibliogràfiques
Publicat a:Dev Neurosci
Autors principals: Tien, Lu-Tai, Lee, Yih-Jing, Pang, Yi, Lu, Silu, Lee, Jonathan W, Tseng, Chih-Hsueh, Bhatt, Abhay J, Savich, Renate D, Fan, Lir-Wan
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799046/
https://ncbi.nlm.nih.gov/pubmed/28787734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000477898
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