Neuroprotective effects of intranasal IGF-1 against neonatal lipopolysaccharide-induced neurobehavioral deficits and neuronal inflammation in the substantia nigra and locus coeruleus of juvenile rats

Neonatal lipopolysaccharide (LPS) exposure-induced brain inflammation resulted in motor dysfunction and brain dopaminergic neuronal injury, and increased the risks of neurodegenerative disorders in adult rats. Our previous studies showed that intranasal administration of insulin-like growth factor-1...

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Foilsithe in:Dev Neurosci
Main Authors: Tien, Lu-Tai, Lee, Yih-Jing, Pang, Yi, Lu, Silu, Lee, Jonathan W, Tseng, Chih-Hsueh, Bhatt, Abhay J, Savich, Renate D, Fan, Lir-Wan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799046/
https://ncbi.nlm.nih.gov/pubmed/28787734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000477898
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