Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model

Limited information is available on the pharmacokinetic (PK) and pharmacodynamic (PD) parameters driving the efficacy of antimalarial drugs. Our objective in this study was to determine dose-response relationships of a panel of related spiroindolone analogs and identify the PK-PD index that correlat...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Lakshminarayana, Suresh B., Freymond, Céline, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan K. S., Ho, Paul C., Dartois, Véronique, Diagana, Thierry T., Rottmann, Matthias, Blasco, Francesca
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335872/
https://ncbi.nlm.nih.gov/pubmed/25487807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03274-14
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