In Vitro Resistance Studies with Bacteria That Exhibit Low Mutation Frequencies: Prediction of “Antimutant” Linezolid Concentrations Using a Mixed Inoculum Containing both Susceptible and Resistant Staphylococcus aureus

Bacterial resistance studies using in vitro dynamic models are highly dependent on the starting inoculum that might or might not contain spontaneously resistant mutants (RMs). To delineate concentration-resistance relationships with linezolid-exposed Staphylococcus aureus, a mixed inoculum containin...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Firsov, Alexander A., Golikova, Maria V., Strukova, Elena N., Portnoy, Yury A., Romanov, Andrey V., Edelstein, Mikhail V., Zinner, Stephen H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335834/
https://ncbi.nlm.nih.gov/pubmed/25451050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04214-14
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