In Vitro Resistance Studies with Bacteria That Exhibit Low Mutation Frequencies: Prediction of “Antimutant” Linezolid Concentrations Using a Mixed Inoculum Containing both Susceptible and Resistant Staphylococcus aureus

Bacterial resistance studies using in vitro dynamic models are highly dependent on the starting inoculum that might or might not contain spontaneously resistant mutants (RMs). To delineate concentration-resistance relationships with linezolid-exposed Staphylococcus aureus, a mixed inoculum containin...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Firsov, Alexander A., Golikova, Maria V., Strukova, Elena N., Portnoy, Yury A., Romanov, Andrey V., Edelstein, Mikhail V., Zinner, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335834/
https://ncbi.nlm.nih.gov/pubmed/25451050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04214-14
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