Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

BACKGROUND & AIMS: Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear an...

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Detaylı Bibliyografya
Yayımlandı:J Hepatol
Asıl Yazarlar: Baxter, Melissa, Withey, Sarah, Harrison, Sean, Segeritz, Charis-Patricia, Zhang, Fang, Atkinson-Dell, Rebecca, Rowe, Cliff, Gerrard, Dave T., Sison-Young, Rowena, Jenkins, Roz, Henry, Joanne, Berry, Andrew A., Mohamet, Lisa, Best, Marie, Fenwick, Stephen W., Malik, Hassan, Kitteringham, Neil R., Goldring, Chris E., Piper Hanley, Karen, Vallier, Ludovic, Hanley, Neil A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334496/
https://ncbi.nlm.nih.gov/pubmed/25457200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2014.10.016
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