Nucleolar Targeting by Platinum: p53-Independent Apoptosis Follows rRNA Inhibition, Cell-Cycle Arrest, and DNA Compaction

[Image: see text] TriplatinNC is a highly positively charged, substitution-inert derivative of the phase II clinical anticancer drug, BBR3464. Such substitution-inert complexes form a distinct subset of polynuclear platinum complexes (PPCs) interacting with DNA and other biomolecules through noncova...

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Udgivet i:Mol Pharm
Main Authors: Peterson, Erica J., Menon, Vijay R., Gatti, Laura, Kipping, Ralph, Dewasinghe, Dilhara, Perego, Paola, Povirk, Lawrence F., Farrell, Nicholas P.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334294/
https://ncbi.nlm.nih.gov/pubmed/25407898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp5006867
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