Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

Delivery of siRNA is a key hurdle to realizing the therapeutic promise of RNAi. By targeting internalizing cell surface antigens, antibody–siRNA complexes provide a possible solution. However, initial reports of antibody–siRNA complexes relied on non-specific charged interactions and have not been b...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Cuellar, Trinna L., Barnes, Dwight, Nelson, Christopher, Tanguay, Joshua, Yu, Shang-Fan, Wen, Xiaohui, Scales, Suzie J., Gesch, Julie, Davis, David, van Brabant Smith, Anja, Leake, Devin, Vandlen, Richard, Siebel, Christian W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333408/
https://ncbi.nlm.nih.gov/pubmed/25550431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1362
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