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CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells

Controllable gene delivery via vector-based systems remains a formidable challenge in mammalian synthetic biology and a desirable asset in gene therapy applications. Here, we introduce a methodology to control the copies and residence time of a gene product delivered in host human cells but also sel...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Moore, Richard, Spinhirne, Alec, Lai, Michael J., Preisser, Samantha, Li, Yi, Kang, Taek, Bleris, Leonidas
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333380/
https://ncbi.nlm.nih.gov/pubmed/25527740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1326
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