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MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells

The p53 tumor suppressor protein plays a critical role in cellular stress and cancer prevention. A number of post-transcriptional regulators, termed microRNAs, are closely connected with the p53-mediated cellular networks. While the molecular interactions among p53 and microRNAs have emerged, a syst...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Moore, Richard, Ooi, Hsu Kiang, Kang, Taek, Bleris, Leonidas, Ma, Lan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671655/
https://ncbi.nlm.nih.gov/pubmed/26642352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004653
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