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Modular construction of mammalian gene circuits using TALE transcriptional repressors

An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable parts. However, engineering of complex circuits in mammalian cells is currently limited by the availability of well-characterized and orthogo...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Li, Yinqing, Jiang, Yun, Chen, He, Liao, Weixi, Li, Zhihua, Weiss, Ron, Xie, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333066/
https://ncbi.nlm.nih.gov/pubmed/25643171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1736
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