Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine

Hexameric AAA+ unfoldases of ATP-dependent proteases and protein-remodeling machines use conserved loops that line the axial pore to apply force to substrates during the mechanical processes of protein unfolding and translocation. Whether loops from multiple subunits act independently or coordinatel...

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Udgivet i:Nat Chem Biol
Main Authors: Iosefson, Ohad, Nager, Andrew R., Baker, Tania A., Sauer, Robert T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333055/
https://ncbi.nlm.nih.gov/pubmed/25599533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1732
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