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Anthracyclines induce double-strand DNA breaks at active gene promoters
Doxorubicin is a widely used chemotherapeutic drug that intercalates between DNA base-pairs and poisons Topoisomerase II, although the mechanistic basis for cell killing remains speculative. Doxorubicin and related anthracycline compounds have been shown to increase nucleosome turnover and/or evicti...
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| Publicado no: | Mutat Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4332850/ https://ncbi.nlm.nih.gov/pubmed/25705119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.01.007 |
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