Use of the HPRT gene to study nuclease-induced DNA double-strand break repair

Understanding the mechanisms of chromosomal double-strand break repair (DSBR) provides insight into genome instability, oncogenesis and genome engineering, including disease gene correction. Research into DSBR exploits rare-cutting endonucleases to cleave exogenous reporter constructs integrated int...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Gravells, Polly, Ahrabi, Sara, Vangala, Rajani K., Tomita, Kazunori, Brash, James T., Brustle, Lena A., Chung, Christopher, Hong, Julia M., Kaloudi, Aikaterini, Humphrey, Timothy C., Porter, Andrew C.G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654060/
https://ncbi.nlm.nih.gov/pubmed/26423459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv409
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