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Preferential Repair of DNA Double-strand Break at the Active Gene in Vivo

Previous studies have demonstrated transcription-coupled nucleotide/base excision repair. We report here for the first time that DNA double-strand break (DSB) repair is also coupled to transcription. We generated a yeast strain by introducing a homing (Ho) endonuclease cut site followed by a nucleot...

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Detalhes bibliográficos
Main Authors: Chaurasia, Priyasri, Sen, Rwik, Pandita, Tej K., Bhaumik, Sukesh R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476307/
https://ncbi.nlm.nih.gov/pubmed/22910905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364661
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