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Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks

DNA synthesis during homologous recombination is highly mutagenic and prone to template switches. Two‐ended DNA double‐strand breaks (DSBs) are usually repaired by gene conversion with a short patch of DNA synthesis, thus limiting the mutation load to the vicinity of the DSB. Single‐ended DSBs are r...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:EMBO J
Päätekijät: Pham, Nhung, Yan, Zhenxin, Yu, Yang, Faria Afreen, Mosammat, Malkova, Anna, Haber, James E, Ira, Grzegorz
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126933/
https://ncbi.nlm.nih.gov/pubmed/33844333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104847
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