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Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks

DNA synthesis during homologous recombination is highly mutagenic and prone to template switches. Two‐ended DNA double‐strand breaks (DSBs) are usually repaired by gene conversion with a short patch of DNA synthesis, thus limiting the mutation load to the vicinity of the DSB. Single‐ended DSBs are r...

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Foilsithe in:EMBO J
Main Authors: Pham, Nhung, Yan, Zhenxin, Yu, Yang, Faria Afreen, Mosammat, Malkova, Anna, Haber, James E, Ira, Grzegorz
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126933/
https://ncbi.nlm.nih.gov/pubmed/33844333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104847
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