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Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks
DNA synthesis during homologous recombination is highly mutagenic and prone to template switches. Two‐ended DNA double‐strand breaks (DSBs) are usually repaired by gene conversion with a short patch of DNA synthesis, thus limiting the mutation load to the vicinity of the DSB. Single‐ended DSBs are r...
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| Опубликовано в: : | EMBO J |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley and Sons Inc.
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8126933/ https://ncbi.nlm.nih.gov/pubmed/33844333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104847 |
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