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Mechanisms restraining break‐induced replication at two‐ended DNA double‐strand breaks

DNA synthesis during homologous recombination is highly mutagenic and prone to template switches. Two‐ended DNA double‐strand breaks (DSBs) are usually repaired by gene conversion with a short patch of DNA synthesis, thus limiting the mutation load to the vicinity of the DSB. Single‐ended DSBs are r...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Pham, Nhung, Yan, Zhenxin, Yu, Yang, Faria Afreen, Mosammat, Malkova, Anna, Haber, James E, Ira, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126933/
https://ncbi.nlm.nih.gov/pubmed/33844333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104847
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