Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation

Pancreatic ductal adenocarcinoma (PDA) is the most aggressive tumor, showing incidence and mortality values almost identical. Despite remarkable advances in PDA molecular characterization, this disease is still refractory to current treatments. Desmoplastic stroma, a constant hallmark of PDA, has re...

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Vydáno v:Cancer Res
Hlavní autoři: Martínez-Bosch, Neus, Fernández-Barrena, Maite G., Moreno, Mireia, Ortiz-Zapater, Elena, André, Sabine, Gabius, Hans-Joachim, Hwang, Rosa F., Poirier, Françoise, Munné-Collado, Jessica, Iglesias, Mar, Navas, Carolina, Guerra, Carmen, Fernández-Zapico, Martin E., Navarro, Pilar
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332591/
https://ncbi.nlm.nih.gov/pubmed/24812270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3013
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