Subunit Interfaces Contribute Differently to Activation and Allosteric Modulation of Neuronal Nicotinic Acetylcholine Receptors

Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in the nervous system and are implicated in many normal and pathological processes. The structural determinants of allostery in nAChRs are not well understood. One class of nAChR allosteric modulators, including the small mol...

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Veröffentlicht in:Neuropharmacology
Hauptverfasser: Short, Caitlin A., Cao, Angela T., Wingfield, Molly A., Doers, Matthew E., Jobe, Emily M., Wang, Nan, Levandoski, Mark M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332533/
https://ncbi.nlm.nih.gov/pubmed/25486620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.11.027
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