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Intra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors

Allosteric modulation is a general feature of nicotinic acetylcholine receptors, yet the structural components and movements important for conversions among functional states are not well understood. In this study, we examine the communication between the binding sites for agonist and the modulator...

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Autori principali: Chrisman, Paul A., Podair, Julie I., Jobe, Emily M., Levandoski, Mark M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970552/
https://ncbi.nlm.nih.gov/pubmed/24373904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.12.017
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