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Specificity Determinants of Allosteric Modulation in the Neuronal Nicotinic Acetylcholine Receptor: a Fine Line between Inhibition and Potentiation
We are interested in the allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs). We have postulated that the anthelmintic morantel (Mor) positively modulates (potentiates) rat α3β2 receptors through a site located at the β(+)/α(−) interface that is homologous to the canonical a...
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| Hoofdauteurs: | , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263947/ https://ncbi.nlm.nih.gov/pubmed/22064677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.076059 |
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