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Morantel Allosterically Enhances Channel Gating of Neuronal Nicotinic Acetylcholine α3β2 Receptors

We studied allosteric potentiation of rat α3β2 neuronal nicotinic acetylcholine receptors (nAChRs) by the anthelmintic compound morantel. Macroscopic currents evoked by acetylcholine (ACh) from nAChRs expressed in Xenopus laevis oocytes increase up to 8-fold in the presence of low concentrations of...

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Détails bibliographiques
Auteurs principaux: Wu, Tse-Yu, Smith, Caleb M., Sine, Steven M., Levandoski, Mark M.
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587017/
https://ncbi.nlm.nih.gov/pubmed/18458055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.044388
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