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Morantel Allosterically Enhances Channel Gating of Neuronal Nicotinic Acetylcholine α3β2 Receptors

We studied allosteric potentiation of rat α3β2 neuronal nicotinic acetylcholine receptors (nAChRs) by the anthelmintic compound morantel. Macroscopic currents evoked by acetylcholine (ACh) from nAChRs expressed in Xenopus laevis oocytes increase up to 8-fold in the presence of low concentrations of...

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Bibliografische gegevens
Hoofdauteurs: Wu, Tse-Yu, Smith, Caleb M., Sine, Steven M., Levandoski, Mark M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587017/
https://ncbi.nlm.nih.gov/pubmed/18458055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.044388
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