MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts

Age-related defects in fibroblast differentiation were previously shown to be associated with impaired hyaluronan synthase 2 (HAS2) and epidermal growth factor receptor (EGFR) function, with both required for normal fibroblast functionality. In fibroblasts, transforming growth factor-beta 1 (TGF-β1)...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Midgley, Adam C, Bowen, Timothy, Phillips, Aled O, Steadman, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331777/
https://ncbi.nlm.nih.gov/pubmed/24134702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12167
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