Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts

Fibroblast to myofibroblast differentiation drives effective wound healing and is largely regulated by the cytokine transforming growth factor-β1 (TGF-β1). Myofibroblasts express α-smooth muscle actin and are present in granulation tissue, where they are responsible for wound contraction. Our previo...

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Detalhes bibliográficos
Main Authors: Midgley, Adam C., Rogers, Mathew, Hallett, Maurice B., Clayton, Aled, Bowen, Timothy, Phillips, Aled O., Steadman, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663506/
https://ncbi.nlm.nih.gov/pubmed/23589287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.451336
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