Hyaluronan Regulates Bone Morphogenetic Protein-7-dependent Prevention and Reversal of Myofibroblast Phenotype

Hyaluronan (HA) promotes transforming growth factor (TGF)-β1-driven myofibroblast phenotype. However, HA can also have disease-limiting activity. Bone morphogenetic protein-7 (BMP7) is an antifibrotic cytokine that antagonizes TGF-β1, and isolated studies have demonstrated that HA can both mediate a...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Midgley, Adam C., Duggal, Lucy, Jenkins, Robert, Hascall, Vincent, Steadman, Robert, Phillips, Aled O., Meran, Soma
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
Glycobiology and Extracellular Matrices
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416830/
https://ncbi.nlm.nih.gov/pubmed/25716319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625939
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