Hyaluronidase-2 Regulates RhoA Signaling, Myofibroblast Contractility, and Other Key Profibrotic Myofibroblast Functions

Hyaluronidase (HYAL)-2 is a weak, acid-active, hyaluronan-degrading enzyme broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactive; thus the mechanisms through which HYAL2 dysregulation i...

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Udgivet i:Am J Pathol
Main Authors: Midgley, Adam C., Woods, Emma L., Jenkins, Robert H., Brown, Charlotte, Khalid, Usman, Chavez, Rafael, Hascall, Vincent, Steadman, Robert, Phillips, Aled O., Meran, Soma
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7254050/
https://ncbi.nlm.nih.gov/pubmed/32201263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.02.012
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