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LAPTM4B is a PtdIns(4,5)P(2) effector that regulates EGFR signaling, lysosomal sorting, and degradation
Lysosomal degradation is essential for the termination of EGF-stimulated EGF receptor (EGFR) signaling. This requires EGFR sorting to the intraluminal vesicles (ILVs) of multi-vesicular endosomes (MVEs). Cytosolic proteins including the ESCRT machineries are key regulators of EGFR intraluminal sorti...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331002/ https://ncbi.nlm.nih.gov/pubmed/25588945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489425 |
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