Immune-mediated antitumor effect by type 2 diabetes drug, metformin

Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer effects; however, the underlying mechanism is poorly understood. Here we show that this mechanism may be immune-mediated. Metformin enabled normal but not T-cell–deficient SCID mice to reject solid tumors. In add...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Eikawa, Shingo, Nishida, Mikako, Mizukami, Shusaku, Yamazaki, Chihiro, Nakayama, Eiichi, Udono, Heiichiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330733/
https://ncbi.nlm.nih.gov/pubmed/25624476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417636112
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