Attenuation of CD4(+) CD25(+) Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

CD4(+) CD25(+) regulatory T cells (Treg), an essential subset for preventing autoimmune diseases, is implicated as a negative regulator in anti-tumor immunity. We found that metformin (Met) reduced tumor-infiltrating Treg (Ti-Treg), particularly the terminally-differentiated CD103(+) KLRG1(+) popula...

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Enregistré dans:
Détails bibliographiques
Publié dans:EBioMedicine
Auteurs principaux: Kunisada, Yuki, Eikawa, Shingo, Tomonobu, Nahoko, Domae, Shohei, Uehara, Takenori, Hori, Shohei, Furusawa, Yukihiro, Hase, Koji, Sasaki, Akira, Udono, Heiichiro
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704053/
https://ncbi.nlm.nih.gov/pubmed/29066174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.10.009
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