Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis

The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Nojima, Ichiro, Eikawa, Shingo, Tomonobu, Nahoko, Hada, Yoshiko, Kajitani, Nobuo, Teshigawara, Sanae, Miyamoto, Satoshi, Tone, Atsuhito, Uchida, Haruhito A., Nakatsuka, Atsuko, Eguchi, Jun, Shikata, Kenichi, Udono, Heiichiro, Wada, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484782/
https://ncbi.nlm.nih.gov/pubmed/32913271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71946-3
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi