Metformin induces CD11b(+)-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

CD11b(+) myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell-mediated anti-tumor immunity. Regulation of these cell types is a primary goal for achieving efficient cancer immunotherapy. We...

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Detalhes bibliográficos
Publicado no:Int Immunol
Main Authors: Uehara, Takenori, Eikawa, Shingo, Nishida, Mikako, Kunisada, Yuki, Yoshida, Aki, Fujiwara, Tomohiro, Kunisada, Toshiyuki, Ozaki, Toshifumi, Udono, Heiichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440441/
https://ncbi.nlm.nih.gov/pubmed/30508092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxy079
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