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A moonlighting metabolic protein influences repair at DNA double-stranded breaks

Catalytically active proteins with divergent dual functions are often described as ‘moonlighting’. In this work we characterize a new, chromatin-based function of Lys20, a moonlighting protein that is well known for its role in metabolism. Lys20 was initially described as homocitrate synthase (HCS),...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Torres-Machorro, Ana Lilia, Aris, John P., Pillus, Lorraine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330366/
https://ncbi.nlm.nih.gov/pubmed/25628362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1405
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