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Facile synthesis of borofragments and their evaluation in activity-based protein profiling

The discovery of enzyme inhibitors relies on synthetic methods that enable rapid and modular construction of small molecules. Heterocyclic fragments designed to maximize enthalpic interactions with their protein targets represent a particularly desirable class of molecules. Here we describe a reagen...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Adachi, Shinya, Cognetta, Armand B., Niphakis, Micah J., He, Zhi, Zajdlik, Adam, St Denis, Jeffrey D., Scully, Conor C. G., Cravatt, Benjamin F., Yudin, Andrei K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330092/
https://ncbi.nlm.nih.gov/pubmed/25633248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc09107h
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