Discovery of Autophagy Inhibitors with Antiproliferative Activity in Lung and Pancreatic Cancer Cells

[Image: see text] The autophagy inhibitors chloroquine (CQ) and hydroxychloroquine (HCQ) have single agent antiproliferative activity against human cancer cell lines; however, low potency may limit their antitumor efficacy clinically. We synthesized a series of chloroquine analogs that retained the...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Nordstrøm, Lars Ulrik, Sironi, Juan, Aranda, Evelyn, Maisonet, Jorge, Perez-Soler, Roman, Wu, Peng, Schwartz, Edward L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2015
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329578/
https://ncbi.nlm.nih.gov/pubmed/25699157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500348p
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