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The autophagy inhibitor chloroquine overcomes the innate resistance to erlotinib of non-small cell lung cancer cells with wild-type EGFR

INTRODUCTION: The EGFR inhibitor erlotinib is much less effective in NSCLC tumors with wild-type EGFR than in tumors with activating EGFR mutations. Autophagy is a tightly regulated lysosomal self-digestion process that may alternatively promote cell survival or type II cell death. This study assess...

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Detalhes bibliográficos
Main Authors: Zou, Yiyu, Ling, Yi-He, Sironi, Juan, Schwartz, Edward L., Perez-Soler, Roman, Piperdi, Bilal
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855301/
https://ncbi.nlm.nih.gov/pubmed/23575415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31828c7210
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