Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of macroautophagy might provide a novel therapeutic strate...

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Detaylı Bibliyografya
Yayımlandı:EMBO Mol Med
Asıl Yazarlar: Schiebler, Mark, Brown, Karen, Hegyi, Krisztina, Newton, Sandra M, Renna, Maurizio, Hepburn, Lucy, Klapholz, Catherine, Coulter, Sarah, Obregón-Henao, Andres, Henao Tamayo, Marcela, Basaraba, Randall, Kampmann, Beate, Henry, Katherine M, Burgon, Joseph, Renshaw, Stephen A, Fleming, Angeleen, Kay, Robert R, Anderson, Karen E, Hawkins, Phillip T, Ordway, Diane J, Rubinsztein, David C, Floto, Rodrigo Andres
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BlackWell Publishing Ltd 2015
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4328644/
https://ncbi.nlm.nih.gov/pubmed/25535254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404137
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