Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of macroautophagy might provide a novel therapeutic strate...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Schiebler, Mark, Brown, Karen, Hegyi, Krisztina, Newton, Sandra M, Renna, Maurizio, Hepburn, Lucy, Klapholz, Catherine, Coulter, Sarah, Obregón-Henao, Andres, Henao Tamayo, Marcela, Basaraba, Randall, Kampmann, Beate, Henry, Katherine M, Burgon, Joseph, Renshaw, Stephen A, Fleming, Angeleen, Kay, Robert R, Anderson, Karen E, Hawkins, Phillip T, Ordway, Diane J, Rubinsztein, David C, Floto, Rodrigo Andres
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4328644/
https://ncbi.nlm.nih.gov/pubmed/25535254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404137
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