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Functional drug screening reveals anticonvulsants as enhancers of mTOR-independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement of macroautophagy might provide a novel therapeutic strate...
Kaydedildi:
| Yayımlandı: | EMBO Mol Med |
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| Asıl Yazarlar: | , , , , , , , , , , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BlackWell Publishing Ltd
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4328644/ https://ncbi.nlm.nih.gov/pubmed/25535254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404137 |
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