Lithium induces autophagy by inhibiting inositol monophosphatase

Macroautophagy is a key pathway for the clearance of aggregate-prone cytosolic proteins. Currently, the only suitable pharmacologic strategy for up-regulating autophagy in mammalian cells is to use rapamycin, which inhibits the mammalian target of rapamycin (mTOR), a negative regulator of autophagy....

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Detalhes bibliográficos
Main Authors: Sarkar, Sovan, Floto, R. Andres, Berger, Zdenek, Imarisio, Sara, Cordenier, Axelle, Pasco, Matthieu, Cook, Lynnette J., Rubinsztein, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171537/
https://ncbi.nlm.nih.gov/pubmed/16186256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504035
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