Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques

BACKGROUND AND PURPOSE: Lithium chloride (LiCl) inhibits inositol monophosphatase (IMPase) at therapeutic concentrations. Given that LiCl induces death in cultured macrophages and that macrophages play an active role in atherosclerotic plaque destabilization, we investigated whether LiCl would induc...

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Autores principales: De Meyer, Inge, Martinet, Wim, Van Hove, Cor E, Schrijvers, Dorien M, Hoymans, Vicky Y, Van Vaeck, Luc, Fransen, Paul, Bult, Hidde, De Meyer, Guido RY
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2011
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058172/
https://ncbi.nlm.nih.gov/pubmed/21138421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01152.x
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