Characterization of the Novel DNA Gyrase Inhibitor AZD0914: Low Resistance Potential and Lack of Cross-Resistance in Neisseria gonorrhoeae

The unmet medical need for novel intervention strategies to treat Neisseria gonorrhoeae infections is significant and increasing, as rapidly emerging resistance in this pathogen is threatening to eliminate the currently available treatment options. AZD0914 is a novel bacterial gyrase inhibitor that...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Alm, Richard A., Lahiri, Sushmita D., Kutschke, Amy, Otterson, Linda G., McLaughlin, Robert E., Whiteaker, James D., Lewis, Lisa A., Su, Xiaohong, Huband, Michael D., Gardner, Humphrey, Mueller, John P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325766/
https://ncbi.nlm.nih.gov/pubmed/25534723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04456-14
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