Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

We characterized the inhibition of Neisseria gonorrhoeae type II topoisomerases gyrase and topoisomerase IV by AZD0914 (AZD0914 will be henceforth known as ETX0914 (Entasis Therapeutics)), a novel spiropyrimidinetrione antibacterial compound that is currently in clinical trials for treatment of drug...

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Foilsithe in:J Biol Chem
Main Authors: Kern, Gunther, Palmer, Tiffany, Ehmann, David E., Shapiro, Adam B., Andrews, Beth, Basarab, Gregory S., Doig, Peter, Fan, Jun, Gao, Ning, Mills, Scott D., Mueller, John, Sriram, Shubha, Thresher, Jason, Walkup, Grant K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Enzymology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543657/
https://ncbi.nlm.nih.gov/pubmed/26149691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663534
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