Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

We characterized the inhibition of Neisseria gonorrhoeae type II topoisomerases gyrase and topoisomerase IV by AZD0914 (AZD0914 will be henceforth known as ETX0914 (Entasis Therapeutics)), a novel spiropyrimidinetrione antibacterial compound that is currently in clinical trials for treatment of drug...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Kern, Gunther, Palmer, Tiffany, Ehmann, David E., Shapiro, Adam B., Andrews, Beth, Basarab, Gregory S., Doig, Peter, Fan, Jun, Gao, Ning, Mills, Scott D., Mueller, John, Sriram, Shubha, Thresher, Jason, Walkup, Grant K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543657/
https://ncbi.nlm.nih.gov/pubmed/26149691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.663534
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