High In Vitro Activity of the Novel Spiropyrimidinetrione AZD0914, a DNA Gyrase Inhibitor, against Multidrug-Resistant Neisseria gonorrhoeae Isolates Suggests a New Effective Option for Oral Treatment of Gonorrhea

We evaluated the activity of the novel spiropyrimidinetrione AZD0914 (DNA gyrase inhibitor) against clinical gonococcal isolates and international reference strains (n = 250), including strains with diverse multidrug resistance and extensive drug resistance. The AZD0914 MICs were substantially lower...

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Detalhes bibliográficos
Main Authors: Jacobsson, Susanne, Golparian, Daniel, Alm, Richard A., Huband, Michael, Mueller, John, Jensen, Jorgen Skov, Ohnishi, Makoto, Unemo, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135813/
https://ncbi.nlm.nih.gov/pubmed/24982070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03090-14
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