EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstrate that the catalytic subunit of Polycomb repress...

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發表在:Stem Cell Reports
Main Authors: Kim, Sung-Hak, Joshi, Kaushal, Ezhilarasan, Ravesanker, Myers, Toshia R., Siu, Jason, Gu, Chunyu, Nakano-Okuno, Mariko, Taylor, David, Minata, Mutsuko, Sulman, Erik P., Lee, Jeongwu, Bhat, Krishna P.L., Salcini, Anna Elisabetta, Nakano, Ichiro
格式: Artigo
語言:Inglês
出版: Elsevier 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325196/
https://ncbi.nlm.nih.gov/pubmed/25601206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.12.006
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