EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstrate that the catalytic subunit of Polycomb repress...

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Foilsithe in:Stem Cell Reports
Main Authors: Kim, Sung-Hak, Joshi, Kaushal, Ezhilarasan, Ravesanker, Myers, Toshia R., Siu, Jason, Gu, Chunyu, Nakano-Okuno, Mariko, Taylor, David, Minata, Mutsuko, Sulman, Erik P., Lee, Jeongwu, Bhat, Krishna P.L., Salcini, Anna Elisabetta, Nakano, Ichiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325196/
https://ncbi.nlm.nih.gov/pubmed/25601206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.12.006
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