EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstrate that the catalytic subunit of Polycomb repress...

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Publicado en:Stem Cell Reports
Autores principales: Kim, Sung-Hak, Joshi, Kaushal, Ezhilarasan, Ravesanker, Myers, Toshia R., Siu, Jason, Gu, Chunyu, Nakano-Okuno, Mariko, Taylor, David, Minata, Mutsuko, Sulman, Erik P., Lee, Jeongwu, Bhat, Krishna P.L., Salcini, Anna Elisabetta, Nakano, Ichiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325196/
https://ncbi.nlm.nih.gov/pubmed/25601206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.12.006
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