Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition

Glioblastoma multiforme (GBM) is a highly lethal brain tumor. Due to resistance to current therapies, patient prognosis remains poor and development of novel and effective GBM therapy is crucial. Glioma stem cells (GSCs) have gained attention as a therapeutic target in GBM due to their relative resi...

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Detalhes bibliográficos
Main Authors: Minata, Mutsuko, Gu, Chunyu, Joshi, Kaushal, Nakano-Okuno, Mariko, Hong, Christopher, Nguyen, Chi-Hung, Kornblum, Harley I., Molla, Annie, Nakano, Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989164/
https://ncbi.nlm.nih.gov/pubmed/24739874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092546
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