Multi-Kinase Inhibitor C1 Triggers Mitotic Catastrophe of Glioma Stem Cells Mainly through MELK Kinase Inhibition

Glioblastoma multiforme (GBM) is a highly lethal brain tumor. Due to resistance to current therapies, patient prognosis remains poor and development of novel and effective GBM therapy is crucial. Glioma stem cells (GSCs) have gained attention as a therapeutic target in GBM due to their relative resi...

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Autores principales: Minata, Mutsuko, Gu, Chunyu, Joshi, Kaushal, Nakano-Okuno, Mariko, Hong, Christopher, Nguyen, Chi-Hung, Kornblum, Harley I., Molla, Annie, Nakano, Ichiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989164/
https://ncbi.nlm.nih.gov/pubmed/24739874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092546
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