Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway

Glioblastoma multiforme (GBM) is a devastating disease, and the current therapies have only palliative effect. Evidence is mounting to indicate that brain tumor stem cells (BTSCs) are a minority of tumor cells that are responsible for cancer initiation, propagation, and maintenance. Therapies that f...

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Detalhes bibliográficos
Main Authors: Nakano, Ichiro, Joshi, Kaushal, Visnyei, Koppany, Hu, Bin, Watanabe, Momoko, Lam, Diana, Wexler, Eric, Saigusa, Kuniyasu, Nakamura, Yuko, Laks, Dan R., Mischel, Paul S., Viapiano, Mariano, Kornblum, Harley I.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107094/
https://ncbi.nlm.nih.gov/pubmed/21558073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor023
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